Peripartum leukocytosis, hypoprothrombinemia, and abnormal hepatic and renal function were noted. Four days prior, she experienced fevers, malaise, nausea and myalgias. Vitamin K in a peripartum patient with acute fatty liver of pregnancy complicated by kidney and liver dysfunction.Ī 24-year-old G 2P 1A 0 woman delivered a healthy infant at 38 weeks gestation. We report a case of a localized cutaneous reaction to intramuscular To vitamin K may arise and have been described in the literature. With repeated injections, cutaneous reactions Phytonadione is available in oral, intramuscular, or intravenous routes. In addition, it serves as an antidote to anticoagulants.Īlthough phytonadione is rather nontoxic, severe adverse reactions can infrequently occur. Prevention of both hypoprothrombinemia and hemorrhagic disease of the newborn. Vitamin K, commonly in the form of phytonadione, is frequently used in the treatment and A deficiency of vitamin K results in symptoms of abnormal bleeding, including epistaxis, hematuria, ecchymoses, and bleedingįrom the gastrointestinal tract. Vitamin K 1 (phylloquinone or phytonadione) is found in plants and Vitamin K 2 (a menaquinone) is synthesized by Gram positive bacteria found in normal intestinal flora. Vitamin K is an essential cofactor for several clotting factors and anticoagulant proteins. With a discussion of the pathogenesis pathogenesis of vitamin K 1 and available treatment for this condition.
The history and clinical presentation of our case is presented We present a case of a localized cutaneous reaction to intramuscular vitamin K 1 in a peripartum patient with acute fatty liver of pregnancy. Erythematous, indurated, pruritic plaques uncommonly occur in adults after intramuscular Vitamin K 1 is frequently used in the treatment and prevention of hypoprothrombinemia and hemorrhagic disease of the newborn. Department of Dermatology, University of Texas Medical Branch, Galveston, Texas. School of Medicine, University of Texas Medical Branch, Galveston, Texasģ. Department of Dermatology, Case Western Reserve-Metro Health Center, Cleveland, OhioĢ. Tatiana Sousa MD 1, Lindsey Hunter BS 2, Matthew Petitt DO 3, Michael George Wilkerson MD 3 Dermatology Online Journal 16 (12): 16 1. Letter: Localized cutaneous reaction to intramuscular vitamin K in a patient with acute fatty liver of pregnancy
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